Fig. 3: VOC pathogenesis in Roborovski dwarf hamsters.
a Schematic of the dwarf hamster pathogenesis study. Animals were monitored for up to 14 days after intranasal infection with 1 × 105 pfu each (VOC delta 3 × 104 pfu per animal). Clinical signs were assessed once daily (red triangles). b, c Body weight (b) and temperature (c) of infected dwarf hamsters. d Survival curves of infected dwarf hamsters from a. e Viral RNA copies in select organs extracted from infected dwarf hamsters 3 days after infection. f Images of lungs from dwarf hamsters mock infected or inoculated with 1 × 105 pfu of WA1, VOC omicron, or VOC gamma 3 days after infection. g Infectious titers from the lungs of dwarf hamsters shown in f. h Schematic of the dwarf hamster pathogenesis study utilizing 1 × 104 pfu of VOC delta and gamma. i Images of lungs extracted from dwarf hamsters mock infected or inoculated with 1 × 104 pfu of VOC omicron or VOC gamma 0.5 (delta) and 1 day (delta and gamma) after infection. j Infectious titers from the lungs of dwarf hamsters shown in i. Symbols represent independent biological repeats (e, g, j), lines intersect group medians (b, c), columns show group medians (e, g, j), and error bars represent 95% confidence intervals. LoD limit of detection, LoQ limit of quantitation. Source data are provided as a Source Data file.
