Fig. 4: Effects of therapeutic molnupiravir on SARS-CoV-2 lung virus load. | Nature Communications

Fig. 4: Effects of therapeutic molnupiravir on SARS-CoV-2 lung virus load.

From: SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Fig. 4

a Schematic of the dwarf hamster efficacy study. Animals were monitored for up to 14 days after intranasal infection with 1 × 104 pfu each. Clinical signs were assessed once daily (red triangles). Groups of dwarf hamsters were euthanized 3 days after infection to assess viral load and perform histological examinations. b Survival curves of infected dwarf hamsters from a. c Infectious titers from the lungs of dwarf hamsters 3 days after infection as shown in a. d Role of biological sex on antiviral efficacy shown in c. Symbols represent independent biological repeats, columns show group medians (c, d), and error bars represent 95% confidence intervals. Significance was determined using unpaired two-tailed t tests (c) or two-way ANOVA with Sidak’s posthoc multiple comparison tests without further adjustments (d); P values are shown. Source data are provided as a Source Data file.

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