Fig. 5: Single oral dose PK properties of molnupiravir in Roborovski dwarf hamsters. | Nature Communications

Fig. 5: Single oral dose PK properties of molnupiravir in Roborovski dwarf hamsters.

From: SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Fig. 5

Male and female dwarf hamsters were gavaged with molnupiravir at (250 mg/kg body weight). a Plasma concentrations of molnupiravir and NHC, determined over a 24-hour period after dosing. b Plasma concentrations from a, showing male and female subgroups; LoD level of detection (0.0193 μM for NHC (shown); 0.0152 μM for molnupiravir). c Tissue distribution of NHC-TP 1-, 8-, and 24-hours after dosing in male and female dwarf hamsters. Symbols show results for individual animals (a–c), columns represent group means (c); n = 4 each per biological sex and time point (a–c). Source data are provided as a Source Data file.

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