Fig. 6: Molnupiravir mitigates lung histopathology in VOC-infected dwarf hamsters. | Nature Communications

Fig. 6: Molnupiravir mitigates lung histopathology in VOC-infected dwarf hamsters.

From: SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Fig. 6

a Images of lungs from dwarf hamsters mock infected or inoculated with 1 × 104 pfu of VOC delta, gamma, or omicron, treated with vehicle or molnupiravir, and harvested 3 days after infection. b Quantitation of macroscopic lesions as a percent of total visible lung surface area for infected dwarf hamsters treated with vehicle or molnupiravir; n values are shown. Mock infected lungs (n = 4) were included as a reference. Symbols represent independent biological repeats, columns show group medians. Significance was determined using unpaired two-tailed t tests; P values are shown. c, d Histopathology (c) and immunohistochemistry (d) of dwarf hamster lung slices from groups harvested 3 days after infection. Staining with hematoxylin and eosin (c) or α-SARS-CoV-2 S (d). Br bronchioles, Bl blood vessel, scale bar 50 μm. Each image represents tissue from an individual animal, all individual animals analyzed are shown in Supplementary Fig. 14. Source data are provided as a Source Data file.

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