Fig. 4: C. difficile and other spore-forming Firmicutes encode a unique family of Zn2+-binding PBPs. | Nature Communications

Fig. 4: C. difficile and other spore-forming Firmicutes encode a unique family of Zn2+-binding PBPs.

From: A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

Fig. 4

a Multiple sequence alignment uncovers a conserved Zn2+-coordinating tetrad in C. difficile PBP2, PBP3, SpoVD, and other spore-forming Firmicutes like Bacillus subtilis (Bs) and Clostridium perfringens (Cp) SpoVD. b The crystal structures of C. difficile PBP3 (cyan) and SpoVD (salmon) at 2.40 Å and 2.20 Å resolution reveal a shared fold and Zn2+-binding motif.

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