Fig. 2: Prognostic relevance of molecular subgroups.

a Kaplan–Meier overall survival curves for the sAML1, sAML2, trisomies, WT1, no event and mNOS subgroups, separated by ELN²⁰¹⁷ scores. A bar plot representing ELN²⁰¹⁷ repartition for each class is included in the lower panel. b Estimates of the concordance index (C-index) derived from Cox regression with a ridge penalty that consider (1) ELN²⁰¹⁷ strata, (2) gene mutations, (3) molecular classes, (4) molecular classes + FLT3^ITD, (5) genetic data (gene mutations and cytogenetics), (6) clinical and demographic, (7) genetic, clinical and demographic and (8) classes, FLT3^ITD, clinical and demographic features using internal 5 fold cross-validation for penalty selection. Top panel includes barplots representing the number of features/categories considered in each model (i.e. 3 for ELN). The centers of the error bars represent the mean; the lower and upper whiskers represent the 95% CIs. Annotated P-values are from two-sided t score test. c Density plots representing the scaled observed hazard (0–1) for the ELN2017 risk categories and the proposed molecular classes. In purple we show the density of risk for each class, in orange we present the subset of cases in class that also have FLT3^ITD. We omitted the density plot for class t(15;17) due to small numbers. The hazard is depicted for overall survival. In all boxplots, the median is indicated by the horizontal line and the first and third quartiles by the box edges. The lower and upper whiskers extend from the hinges to the smallest and largest values, respectively, no further than 1.5 × interquartile range from the hinges.