Fig. 3: Multi-state model for disease progression in the AML NCRI Cohort (n = 2017).
From: Unified classification and risk-stratification in Acute Myeloid Leukemia
a Representation of patient transitions (in numbers) across clinical endpoints (alive (meaning received induction chemotherapy); alive in complete remission; alive in relapse; death without complete remission; death in complete remission; death in relapse).The arrows represent the number of transitioning patients. Circle arrows correspond to number of patients that do not transition. b Stacked transition probabilities (y-axis) across time (x-axis). c Cox volcano plots depicting the association between state transitions and molecular classes and FLT3ITD. The horizontal dotted curve corresponds to the p-value threshold of 0.05 and the vertical one corresponds to β = 0 on the x-axis. Highlighted predictors have a significant effect or have large β coefficients (p-value greater than the threshold: 0.05 here or p-value close to threshold and |β | >1.5). The size of each point corresponds to the frequency of the event. The reference class in the Cox transition models is no events. Wald test p-values are adjusted to correct for multiple comparisons. d Stacked transition probabilities for each class (y-axis) across time (x-axis). The bold lines represent the transition states. We omitted n = 96 patients from the multi-state model for disease progression (2113–96 = 2017) due to missing timepoints.
