Fig. 6: Example presentation of personalized clinical decision support tool for molecular classification and risk stratification.
From: Unified classification and risk-stratification in Acute Myeloid Leukemia
The calculator is derived using the multi-state models that consider data from (n = 3201 total patients, UK-NCRI and AMLSG) all intensively treated. a Input parameters to include cytogenetic, genetic, clinical and demographic are considered to (b) display each patient’s ELN2017 score alongside with the proposed risk group developed in this study. To further improve interpretation confidence, we provided confidence intervals for each sediment plot and probability estimate transitions. The lower and upper whiskers represent the 95% CIs. Stacked sediment plots for each patient represent the likelihood to transition between clinical endpoints across time. X-axis indicates time from diagnosis in years. Y-axis indicates probability for each transition. Black line indicates probability of survival across time. Vertical dotted line indicates the 1 year time frame. Horizontal barplots indicate the probability of attaining each one of these endpoints at selected time (vertical dotted line). c, d Adjacent barplots show the relative contribution of each covariate (molecular, clinical, demographic) on each transition. Estimates can be dynamically derived for the time of diagnosis or upon attainment of Complete Remission (CR) and across timepoints (i.e. Year 1 post diagnosis or CR, Year 3 post diagnosis or CR etc). To further improve interpretation confidence, we provided confidence intervals for each sediment plot and probability estimate transitions. The lower and upper whiskers represent the 95% CIs. Stacked sediment plots for each patient represent the likelihood to transition between clinical endpoints across time. X-axis indicates time from diagnosis in years. Y-axis indicates probability for each transition. Black line indicates probability of survival across time. Vertical dotted line indicates the 1 year time frame. Horizontal barplots indicate the probability of obtaining each one of these endpoints at selected time (vertical dotted line) and at 3 years.
