Fig. 6: Synergy predictions and validation of the high-throughput Combi-Seq screen. | Nature Communications

Fig. 6: Synergy predictions and validation of the high-throughput Combi-Seq screen.

From: Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Fig. 6

a Heatmap showing predicted synergy scores that were determined by comparing viabilities from all 420 drug combinations to corresponding single drug treatments. b Correlation between experimental and predicted cell viability (Pearson correlation r = 0.66, p = 0.018, R2 = 0.44). Drug synergy (y-axis) was measured for 12 combinations in a microtiter plate format (color code) and plotted against the predicted synergy value (x-axis), the shaded area shows a 95% confidence interval of the regression estimate. Source data are provided as a Source Data file.

Back to article page