Fig. 4: Analysis of neprosin activity against gliadin in vivo.
From: Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy
Amount of 33-mer (μg) in the total contents of the stomach (S), proximal small intestine (pSI) and distal small intestine (dSI) of mice receiving neprosin zymogen (N) or vehicle (V) prior to a bolus of gliadin. Results are means ± SEM (n = 8 animals per group). Statistical significance was determined by a one-sided F-test (*p < 0.05, N vs B). The p values were 0.048 (S), 0.049 (pSI), 0.026 (dSI) and 0.021 (Total). Relevant source data are provided as a Source Data file.
