Fig. 3: Normal HSC numbers in mice carrying Cxcr4 deletion in megakaryocytes, myeloid, and lymphoid cells. | Nature Communications

Fig. 3: Normal HSC numbers in mice carrying Cxcr4 deletion in megakaryocytes, myeloid, and lymphoid cells.

From: Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size

Fig. 3

a Schematic representation of CXCR4 deletion in hematopoietic cells by cell-lineage specific cre-recombinase transgenic approaches. b–e LT-HSC numbers in one femur and tibia of control littermate mice (black); (b) Pf4-cre.Cxcr4fl/fl (green, n = 6/group); (c) Lyz2-cre.Cxcr4fl/fl (blue, n = 7/group); (d) Il7ra-cre.Cxcr4fl/fl (yellow, CTR n = 5, KO n = 6); (e) Cd4-cre. Cxcr4fl/fl (purple, n = 3/group). Data are representative of two or more experiments. Bars indicate average, circles depict individual mice. n.s. not significant, P > 0.05 by unpaired two-sided Student’s t test. Source data are provided as a Source Data file.

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