Fig. 5: Comparison of MSPC global transcriptome between control and mice with CXCR4-deficient MPPs. | Nature Communications

Fig. 5: Comparison of MSPC global transcriptome between control and mice with CXCR4-deficient MPPs.

From: Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size

Fig. 5

a Unsupervised hierarchical sample clustering represented as Sample Distance Matrix. CTR (Flk2-cre.Cxcr4fl/+) and KO (Flk2-cre.Cxcr4fl/fl). b Principal-component analysis (PCA) representation of Flk2-cre.Cxcr4fl/+ (CTR) and Flk2-cre.Cxcr4fl/fl (KO) samples obtained from individual mice. c Differentially expressed genes in MSPCs isolated from Flk2-cre.Cxcr4fl/+ (red) and Flk2-cre.Cxcr4fl/fl (blue) mice. Plotted genes showed normalized RNA counts >0 in all samples, FDR adjust p < 0.05. d Heatmap representation of log10 normalized RNA counts of genes important for HSC maintenance and multilineage differentiation. All panels are derived from n = 4 mice per group.

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