Fig. 2: Immune response against ancestral SARS-CoV-2, Delta, and Omicron BA.1 in transplant recipients with non-Omicron SARS-CoV-2 infection (Cohort 1).

A Violin dot plots of the 50% neutralization titers (log₁₀ID50) of neutralizing antibodies against D614G, Delta, and Omicron-BA.1 variants, in transplant recipients infected with non-Omicron variant (primarily ancestral SARS-CoV-2). Each circle represents an individual patient neutralization titer. Horizontal lines represent median values. P values were determined using a two-sided Wilcoxon matched-pairs signed-rank test (D614G vs. Delta p < 0.001, D614G vs. BA.1 p < 0.001). B Scatter plot correlation between the log₁₀ID50 of neutralizing antibody titers against Omicron-BA.1 (x-axis) and Omicron-BA.2 (y-axis) in all patients in Cohort 1 (n = 91). A two-tailed Spearman correlation was performed p < 0.001). The diagonal line represents the best-fit linear regression line. C Proportions of polyfunctional (IFN-γ⁺ and IL-2⁺), IFN-γ monofunctional and IL-2 monofunctional CD4⁺ and D CD8⁺ T cells in transplant recipients recovered from non-Omicron variant infection (subset of Cohort 1, n = 25). Horizontal lines denote the median for each group. A two-sided Wilcoxon matched-pairs signed-rank test with Holm–Šídák correction for multiple comparisons was used. Adjusted P values are shown above each respective comparison. SARS-CoV-2 severe acute respiratory syndrome Coronavirus-2, OMI omicron, IFN-γ interferon gamma, IL-2 interleukin 2. Source data are provided as a Source Data file.