Fig. 1: Humoral response of Syrian hamsters vaccinated with a single dose of AZD2816, a prime dose of AZD1222 and boost dose of AZD2816, or a prime-boost regimen of ChAdOx1 GFP. | Nature Communications

Fig. 1: Humoral response of Syrian hamsters vaccinated with a single dose of AZD2816, a prime dose of AZD1222 and boost dose of AZD2816, or a prime-boost regimen of ChAdOx1 GFP.

From: ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Fig. 1

A Schematic overview of experiment. Hamsters were vaccinated with AZD2816 on day −28, AZD1222 on day −56 and AZD2816 on day −28, or ChAdOx1 GFP at day −56 and −28. Created with BioRender.com. B Boxplot of binding antibodies against S protein of SARS-CoV-2 (ancestral, Beta, or Delta) in serum obtained on day 0. C Boxplot (minimum to maximum) of pseudovirus neutralizing antibody titers in hamster sera obtained on day 0 against ancestral, Beta, Delta, or Omicron VoC. Dotted line = limit of detection. D Boxplot (minimum to maximum) of virus neutralizing antibody titers in hamster sera obtained on day 0 against ancestral, Beta, or Delta VoC. VN titers were normalized against NIBSC standard. Dotted line = limit of detection. Statistical significance was determined via a Friedman test followed by Dunn’s multiple comparisons test, p-values in italic when significant. N = 8 per group, circles = hamsters vaccinated with AZD2816, squares = hamsters vaccinated with AZD1222 followed by AZD2816. All boxplots are drawn from first quartile to third quartile, with a line at the median. Whiskers go from each quartile to minimum or maximum values. Source data are provided as a Source Data file.

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