Fig. 5: Comparative genomics and transcriptomic of rod-shaped and MuLDi Neisseriaceae.

a Phylogenetic tree of Neisseriaceae species (left) and table displaying the distribution, within the family, of putatively inserted (left) or deleted (middle) genes. In addition, selected genes known to be involved in cell growth and/or division are shown (right). Individual genes were considered to be present when they had a sequence similarity ≥60% relative to N. elongata [an e-value cut-off of 1e⁻¹⁰ has also been applied in TBLASTN version 2.7.1 (Altschul et al.¹⁰²). Present genes are indicated with S. muelleri locus_tag (such as RS00570 for BWP33_RS00570). All other genes are indicated with N. elongata locus_tag (such as RS02740 for NELON_RS02740). The putative encoded protein associated with each gene are also specified. The green and black squares indicate genes that are present or absent, respectively. HP hypothetical protein. b Weblogo of the amino acid sequences, of the 7 proteins displaying amino acid permutations rod-shaped or for MuLDi, detected with amino acid permutations between rod-shaped and MuLDi Neisseriaceae. c Volcano-plot: p value is plotted against fold change calculated using DeSeq2. Red and green points correspond to transcripts that are less or more abundant in MuLDi as compared to rod-shaped Neisseriaceae, respectively. Source data and statistics are provided as a Source Data file. d STRING association analysis. ftsA, ftsI and murE from the dcw cluster are highlighted. In red are transcripts that are less abundant in MuLDi Neisseriaceae and in green are transcripts that are more abundant in MuLDi as compared to rod-shaped Neisseriaceae.