Fig. 1: Dual-omics-integrative clustering of KMT2A-r infant ALL. | Nature Communications

Fig. 1: Dual-omics-integrative clustering of KMT2A-r infant ALL.

From: Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Fig. 1

a Comprehensive dual-omics heatmaps of KMT2A-r infant ALL. Top: clinicopathological features of the discovery cohort of 61 infants. The dendrogram is from consensus clustering and indicates sample-to-sample distances. Middle: Expression heatmap of cluster marker genes. The top 100 significantly up- or downregulated marker genes for each of the five ICs were included. Bottom: Methylation heatmap of cluster marker probes. The top 100 significantly hyper- or hypomethylated marker probes for each of the five ICs were included. Number signs (#) indicate the two cases with B/M MPAL. CNS central nervous system, WBC white blood cell, NA not available. b, c Survival analysis comparing the EFS (b) and OS (c) of different ICs of KMT2A-r infant ALL. d Multivariate Cox proportional hazards analysis for EFS. ICs and known clinical prognostic factors, as well as treatment protocols, were included in the model. One patient (MLL_96_063) was excluded due to missing clinical information; a total of 60 infants were included, and the subtotal number of cases in each variable group is indicated. Error bars show the 95% confidence interval. Two-sided raw P values are shown. HR hazard ratio, CI confidence interval.

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