Fig. 2: Integrative comparison of transcriptome and DNA methylome in infant ALL. | Nature Communications

Fig. 2: Integrative comparison of transcriptome and DNA methylome in infant ALL.

From: Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Fig. 2

a, b Integrative scatter plots contrasting expression differences with DNA methylation differences in IC2 (a) and IC4 (b). Genes and probes with significant differences in gene expression (|log2 fold change | ≥2 and two-sided adjusted P < 0.05) and DNA methylation (|Δβ | ≥0.2 and two-sided adjusted P < 0.05) are highlighted in red. c, d Correlated gene expression and DNA methylation of dual-omics cluster markers FLT1 (c), CD34 and MME (d). Pearson correlation coefficients (R) and raw Pearson correlation P values are indicated. Box plots show median and first/third quartiles. The whisker extends from the smallest to the largest values within 1.5 × IQR from the box hinges.

Back to article page