Fig. 4: Mutational landscape of KMT2A-r infant ALL subgroups. | Nature Communications

Fig. 4: Mutational landscape of KMT2A-r infant ALL subgroups.

From: Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Fig. 4

a Gene mutations and CNAs in the different subgroups of KMT2A-r infant leukemia. Number signs (#) indicate the two cases with B/M MPAL. b VAFs of RTK-RAS pathway mutations detected with deep-seq. The VAF of 0.1 is indicated by a dashed horizontal line. Box plots show median and first/third quartiles. c Number of mutations in the RTK-RAS pathway per case. All 61 cases of the discovery cohort are included: IC1 (n = 14), IC2 (n = 14), IC3 (n = 12), IC4 (n = 9), and IC5 (n = 12). Box plots show median and first/third quartiles. Overall P value is from Kruskal–Wallis test. P values for pairwise cluster comparisons are from the two-sided Wilcoxon rank-sum test. *P < 0.05; **P < 0.01; ***P < 0.001. Raw P values are as follows: P = 0.034 (IC2 vs. IC1), 1.2 × 10−3 (IC2 vs. IC3), 7.0 × 10−4 (IC2 vs. IC4), and 1.2 × 10−3 (IC2 vs. IC5). d Survival analysis based on the number of RTK-RAS pathway mutations.

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