Fig. 4: Colocalization of eQTLs with possible hematopoietic trait-causal variants suggested in biobank studies. | Nature Communications

Fig. 4: Colocalization of eQTLs with possible hematopoietic trait-causal variants suggested in biobank studies.

From: The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Fig. 4

a Number of variant-gene-trait pairs (y axis) with suggestive colocalization posterior probabilities (0.01<CLPP), for different hematopoietic traits (x axis) in Biobank Japan (BBJ). b–d Association p value (top), eQTL PIP (second row) and BBJ trait PIP (third row) of the SNVs in ±1 Mb (b, c) or ±100 kb (d) window, as well as the location of the genes (bottom row). The putative causal variants and genes are colored with purple. e The alternative allele frequency of rs2902548 in gnomAD. Additional descriptions about these variant-genes are available in Supplementary Note. f Percentage of variant (y axis) with suggestive hematopoietic trait-causal signal (0.01<PIP) only in Biobank Japan (top), or only in UK Biobank (bottom), for variants with possible putative causal eQTL effects (PIP > 0.1) unique to GTEx (left), or our dataset (right).

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