Fig. 6: Transcriptional interpretation of COVID-19 susceptibility. | Nature Communications

Fig. 6: Transcriptional interpretation of COVID-19 susceptibility.

From: The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Fig. 6

a Volcano plot showing the difference of the RNA expression level between severe and non-severe COVID-19 cases (x axis, log2(severe/non-severe)), and the statistical significance (likelihood ratio test p value, y axis). Color shows the log10(count per million + 1). b GO term enrichment of top-enriched genes in severe cases (n = 198), including genes such as CD177 (Human Neutrophil Alloantigen 2a), or FOXC1 as reported in refs. 46,47. c Cell-type-specific enrichment of the gene sets with different levels of differential expression, for 28 cell types from ImmuNexUT.

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