Fig. 8: COVID-19 severity-interaction eQTLs interacts with composition of various immune cell types. | Nature Communications

Fig. 8: COVID-19 severity-interaction eQTLs interacts with composition of various immune cell types.

From: The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Fig. 8

For each of the 13 genes with COVID-19 severity-interaction eGenes (FDR < 0.05) (= row), significance for interaction eQTL effect with inferred cell type compositions (= columns) are plotted in −log10(p) scale. Colors show the significance as well as the direction of the ieQTL effect relative to the COVID-19 severity (red means severe COVID-19 case corresponds to larger cell type composition in terms of interaction effect, and blue is the other way. Bonferroni p = 1.7 × 10−4 = 0.05/13 genes/22 cell types). Row and columns are sorted based on the number of positive and negative significant results, where three cell types with no significant results are removed.

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