Fig. 4: Longitudinal differences in brain activation between groups. | Nature Communications

Fig. 4: Longitudinal differences in brain activation between groups.

From: A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes

Fig. 4

Results from fMRI analyses showing a greater reduction in activation over time in the Closed Loop (CL) relative to the Standard Care (SC) group. a Line chart showing changes in regional activity over time by group based on mixed-effects modeling conditional on age (Y axis is in arbitrary units or “AU”). The right panel (b, c) shows brain areas that exhibited a significant interaction of group by time in voxel-wise linear mixed effects controlling for age. Significance maps were thresholded using a two-tailed alpha of 0.05, corrected for multiple comparisons. Cool colors indicate reduced activation over time in the CL relative to the SC group. Group by time differences were predominantly located in subregions of the executive function network, including the right inferior frontal gyrus and right parietal cortex as well as the dorsal anterior cingulate cortex. Panel b displays a sagittal view of the brain; panel c displays a coronal view.

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