Fig. 2: Substrate scope of hydroallylation of terminal alkynes.
From: Cobalt-catalyzed branched selective hydroallylation of terminal alkynes
aCondition A: 1 (2 equiv.), 2 (0.50 mmol), (L3-H)•CoBr (5 mol%), PMHS (1.5 equiv.), and LiOtBu (1.5 equiv.) in THF (1 mL) under N2 at rt, isolated yield of 3. bCondition B: 1 (2 equiv.), 2 (0.50 mmol), Co(OAc)2 (5 mol%), L3 (6 mol%), PMHS (1.5 equiv.), and LiOtBu (1.5 equiv.) in THF (1 mL) under N2 at rt, isolated yield of 3. cLG = OP(O)(OPh)2 instead of LG = Br; LG means leaving group. d(L3-H)•CoBr (2 mol%) instead of (L3-H)•CoBr (5 mol%). eLG = I instead of LG = Br. fL7 instead of L3; Si(OSiHMe2)4 instead of PMHS. gL7 instead of L3. h(L3-H)•CoBr (2.5 mol%) instead of (L3-H)•CoBr (5 mol%). iSi(OSiHMe2)4 (2.0 equiv.) instead of PMHS; 0.2 mmol scale.
