Table 1 Circulating sex steroid levels in KiDKO and GoDKO male and female mice at two age windows: peripubertal (4-week-old) and adult (>2-month-old)

From: Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

MALES

Peripubertal (4-wk-old)

Adult (>2 month-old)

 

Control n = 17

KIDKO n = 5

GODKO n = 4

Control n = 43

KIDKO n = 17

GODKO n = 5

Testosterone (pg/mL)

84.96

(25.26, 338.52)

177.48

(60.70, 225.98)

107.32

(63.68, 455.13)

440.93#

(106.97, 17379.55)

82.17a

(5.80, 1635.95)

5.00a,#,1

(5.00, 5.95)

Progesterone (pg/mL)

273.60

(119.90, 584.66)

246.43

(192.80, 302.93)

141.82a

(119.10, 185.60)

122.00#

(43.70, 401,43)

114.23

(43.19, 525.14)

41.98a,b,#

(37.27, 93.32)

FEMALES

Peripubertal (4-wk-old)

Adult (>2 month-old)

 

Control n = 28

KIDKO n = 11

GODKO n = 3

Control n = 36

KIDKO n = 13

GODKO n = 4

Estradiol (pg/mL)

0.512

(0.50, 17.70)

0.503

(0.50, 2.77)

0.504

(0.50, 0.59)

1.76#

(0.5, 14.26)

0.50a

(0.50, 0.71)

<0.50a,5

Progesterone (pg/mL)

169.98

(93.64, 343.19)

174.07

(110.77, 262.62)

157.84

(131.37, 198.99)

492.38#

(70.97, 8262.06)

44.11a,#

(30.42, 120.46)

104.54

(74.34, 252.68)

  1. For males, testosterone and progesterone levels are presented; for females, estradiol and progesterone concentrations are shown.
  2. Data were expressed as Median (min, max). For data analysis, samples below the limit of quantitation (LOQ) of each analyte were assigned the LOQ value (Testosterone: 5 pg/mL; Estradiol: 0.5 pg/mL).
  3. #Statistical differences between adults and peripubertal animals of the same genotype (p < 0.05).
  4. aStatistical differences vs age-matched controls (p < 0.05)
  5. bStatistical differences between GoDKO and age-matched KiDKO mice (p < 0.05).
  6. 1Three out of five samples <LOQ.
  7. 2Thirteen out of 17 samples <LOQ.
  8. 3Nine out of 11 samples <LOQ.
  9. 4Two out of three samples <LOQ.
  10. 5All (four out of four) samples <LOQ.
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