Fig. 2: COVID19 DNA methylation changes regulate autoimmune related functional pathways and associate with environmental respiratory related traits. | Nature Communications

Fig. 2: COVID19 DNA methylation changes regulate autoimmune related functional pathways and associate with environmental respiratory related traits.

From: Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

Fig. 2

a Top 10 significant reactome database pathways (two-tailed hypergeometric p-value < 0.01) are shown by differential analysis. b Number of DMCs with significant interactions for each deconvoluted cell-type proportion (red, B-cells; blue, CD4 + T-cells; orange, CD8 + T-cells; purple, monocytes; blue, neutrophils and green, NK-cells) are split into hypermethylated (upper panels) and hypomethylated (lower panel) and divided into the differential analysis. c EWAS traits enrichments (two-tailed hypergeometric p-value < 1e-10) for each differential analysis are shown (MethBank database). Severe vs negative (blue), mild vs negative (green), severe vs mild (yellow) and pseudotime longitudinal analysis (red).

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