Fig. 2: The generality of BaryPhos-facilitated enantioselective cross-coupling. | Nature Communications

Fig. 2: The generality of BaryPhos-facilitated enantioselective cross-coupling.

From: Enantioselective construction of ortho-sulfur- or nitrogen-substituted axially chiral biaryls and asymmetric synthesis of isoplagiochin D

Fig. 2

Reaction conditions: 1 (0.20 mmol), 2 (0.30 mmol), Pd2(dba)3 (0.5 mol%), (S,S)-BaryPhos (1.0 mol%), K3PO4 (0.60 mmol), Tol/H2O (5 :1), 30 °C, 15 h; the yields refer to isolated yields; the ee value was determined by HPLC. aThermal racemization barrier ΔG‡ = 27.6 kcal/mol (Supplementary Fig. 3a). bThe reaction was conducted at 35 °C in DCE/H2O (5:1), thermal racemization barrier ΔG‡ = 29.0 kcal/mol (Supplementary Fig. 3b).

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