Fig. 2: Escape of BA.4 and BA.5 from immunity elicited by vaccination combined with BA.1 breakthrough infection.
From: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection
a Neutralization of ancestral virus with the D614G substitution, BA.1, BA.4 and BA.5 by vaccine elicited neutralizing immunity with BA.1 breakthrough infection in n = 15 participants. Numbers are geometric mean titer (GMT) FRNT50. Dashed line is most concentrated plasma tested. b Geometric mean (GM) of fold- drops in neutralization and their 95% confidence intervals for BA.4 and BA.5 relative to BA.1 calculated from (a). c GM of fold-drops in neutralization and their 95% confidence intervals for BA.1, BA.4 and BA.5 relative to ancestral/D614G virus calculated from (a). For all panels, green points are values for ancestral/D614G, orange points are BA.1, yellow points are BA.4, and pink points are BA.5. p-values were determined by a two-sided Wilcoxon rank sum test and represented as **0.01-0.001, ***0.001-0.0001, ****<0.0001. Exact p-values were 7.9 × 10−3 for BA.1, 9.7 × 10−5 for BA.4, and 1.9 × 10−4 for BA.5. Source data are provided as a Source Data file.
