Fig. 3: Escape of BA.4 and BA.5 from immunity elicited by vaccination combined in the absence of BA.1 infection.
From: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection
a Neutralization of ancestral/D614G, BA.1, BA.4 and BA.5 by vaccine elicited neutralizing immunity in n = 18 participants. Numbers are geometric mean titer (GMT) FRNT50. Dashed line is most concentrated plasma tested. b Geometric mean (GM) of fold-drops in neutralization and their 95% confidence intervals for BA.4 and BA.5 relative to BA.1 calculated from (a). c GM of fold-drops in neutralization and their 95% confidence intervals for BA.1, BA.4 and BA.5 relative to ancestral/D614G virus calculated from (a). For all panels, green points are values for ancestral/D614G, orange points are BA.1, yellow points are BA.4, and pink points are BA.5. p-values were determined by a two-sided Wilcoxon rank sum test and represented as ****<0.0001. Exact p-values were 7.2 × 10−5 for BA.1, 3.2 × 10−5 for BA.4, and 2.4 × 10−5 for BA.5. Source data are provided as a Source Data file.
