Fig. 2: Systematic dissection of the AP2x enhancer. | Nature Communications

Fig. 2: Systematic dissection of the AP2x enhancer.

From: Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities

Fig. 2

a Schematic representation of elements designed to study the activity of AP2x. The three regions in blue (1–3) indicate highly conserved sequences, while the yellow regions are non-conserved. The different fragments were used to generate transgenic mCherry reporter lines. b-i’ Activity of the different enhancer elements in the maxillary segment during embryonic stages 11 (b-I) and 13 (b’-i’). The AP2x-377 element contains the minimal information for driving AP-2 expression in the maxillary segment, as its enhancer activity is very similar to the full-length AP2x enhancer in both developmental stages. See also Supplementary Figs. 3 and 4.

Back to article page