Fig. 3: Dearomative 1,4-dual functionalization and dearomative cyclization of aryl sulfoxides. | Nature Communications

Fig. 3: Dearomative 1,4-dual functionalization and dearomative cyclization of aryl sulfoxides.

From: Dearomative di- and trifunctionalization of aryl sulfoxides via [5,5]-rearrangement

Fig. 3

Reactions were performed on 0.5 mmol scale under optimal conditions. 5.0 equiv of dienes and 3.0 equiv of dipoles were used in the reaction. 4-ethylmorpholine and Nu were added in one portion (14a-14c, 14j, 15a-15g and 4c′) or in sequence (others). Unless otherwise noted, only one diastereoisomer was obtained. dr = diastereoisomeric ratio. a TMS-protected enol silyl ethers were used. b Nu, −95 °C, 12 h.

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