Fig. 4: The key role of the designed net-carboxylate-arranged cage for conformational modulation.

a Schematic illustration of the synthesis of Cyt c@ZIFs, Cyt c@NU-1000 and Cyt c@HOF-101. The colors used in NU-1000 are: red for O atom; blue for C atom; light green for Zr atom; H atom is removed for clarity. The colors used in HOF-101 are: red for O atom; blue for C atom; white for H atom. The normalized UV–Vis DRS (b) and CAT-like bioactivities of Cyt c@ZIFs, Cyt c@NU-1000 and Cyt c@HOF-101 (c). The dosage of Cyt c in each trial including free Cyt c and different Cyt c nanosystem groups were kept the same (0.1 mg/mL). Error bars (SD) are presented, SD = Standard Deviation (n = 3). Data are presented as mean values ± SD.