Table 2 In epigenome-wide meta-analysis of blood DNA methylation in ADNI and AIBL datasets, comb-p software identified 9 DMRs in the Alzheimer’s disease (AD) vs. cognitive normal groups comparison at 5% Sidak P-values adjusted for multiple comparisons, which were then annotated using the GREAT software and the enhancer regions described in Nasser et al. (2021) study (PMID: 33828297)
From: Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease
DMR | nProbes | P-value | Sidak-P | Direction | GREAT Annotation | Enhancer |
|---|---|---|---|---|---|---|
chr1:205819345-205819464 | 5 | 5.16E-11 | 3.12E-07 | -- | PM20D1 (−160) | No |
chr20:36148672-36148861 | 9 | 1.11E-10 | 4.22E-07 | -- | NNAT (−850) | Yes |
chr1:206786170-206786181 | 3 | 1.67E-10 | 1.09E-05 | ++ | EIF2D (−272) | No |
chr20:36149081-36149232 | 6 | 2.47E-10 | 1.18E-06 | --- | NNAT (−460) | Yes |
chr13:21578684-21578734 | 3 | 8.32E-10 | 1.20E-05 | -- | XPO4 (−101760);LATS2 (+56977) | No |
chr14:56777451-56777526 | 4 | 9.52E-10 | 9.13E-06 | ++ | TMEM260 (−269022);PELI2 (+192396) | No |
chr7:2728841-2728913 | 3 | 4.07E-09 | 4.06E-05 | -- | AMZ1 (+9721);GNA12 (+155081) | Yes |
chr1:202172848-202172913 | 4 | 2.71E-08 | 3.00E-04 | ++ | LGR6 (+9852);UBE2T (+138227) | No |
chr1:223566643-223566710 | 5 | 3.73E-08 | 4.00E-04 | -- | C1orf65 (−38) | No |
