Fig. 5: Prediction results for cognition and symptom across BSNIP-1, fBIRN and COBRE based on the identified PRS-associated features.

The prediction models for each domain were trained based on single site cohort: COBRE. Then the same models and the same ROIs were used to predict cognition/symptom for BSNIP and fBIRN cohorts. Pearson correlation was used to calculated the correlation between the true values and the predicted values in (aāc). The gray regions in (aāc) indicate a 95% confidence interval. Source data are provided as a Source Data file.