Fig. 7: The importance of T lymphocytes and antibodies in the protective immunity elicited by SpiN. | Nature Communications

Fig. 7: The importance of T lymphocytes and antibodies in the protective immunity elicited by SpiN.

From: Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein

Fig. 7

K18-hACE2 mice were immunized with SpiN adjuvanted with Poly ICLC (a, b) or Covishield (e, f) and treated with anti-CD4+, anti-CD8+ or both on days −3, −2, and −1 before infectious challenge. Naïve K18-hACE2 mice were administered, at day −1 before infection, with pooled sera from control or SpiN- (c, d) or Covishield- (g, h) immunized mice. Body weight (a, c, e, g) and survival (b, d, f, h) were monitored for 11 days after infection with the SARS-CoV-2 Wuhan strain. a–h 4 mice/group.

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