Table 1 Comparison of SenMayo with six existing senescence/SASP gene sets

From: A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

 

Human aging

Mouse aging

Mouse genetic clearance of senescent cells

Human pharmacological clearance of senescent cells

 

Cohort A

Cohort B

Microglia

Prefrontal cortex

Dorsal hippocampus

Bone marrow

Mouse INK-ATTAC (old vs young)

Mouse INK-ATTAC (old, vehicle vs AP)

Adipose (Control vs D + Q)

 

NES

p value

NES

p value

NES

p value

NES

p value

NES

p value

NES

p value

NES

p value

NES

p value

NES

p value

R-HSA-2559582

1.1075

0.2826

0.6780

0.9278

1.1794

0.1565

−1.2467

0.1169

1.2117

0.1916

0.9200

0.6043

1.4235

0.0326

1.0006

0.4442

1.1176

0.2356

Casella_up

1.0089

0.4748

0.6970

0.8885

0.9737

0.4790

0.9537

0.5209

1.3949

0.0593

0.8874

0.6339

−1.0861

0.3168

0.6865

0.9627

−0.7959

0.8344

Purcell

0.9329

0.5944

0.9585

0.5093

1.5120

0.0178

1.1731

0.2304

1.8117

0.0000

1.5224

0.0419

1.3894

0.0778

−0.7300

0.8874

0.9132

0.5852

Hernandez

0.7849

0.7771

0.7846

0.7802

0.7146

0.9461

0.8662

0.6710

−0.8100

0.7650

−0.5778

0.9789

1.2513

0.1718

1.4796

0.0266

0.9476

0.5266

Fridman_up

1.4249

0.0169

1.5407

0.0174

1.4397

0.0206

0.9639

0.5449

1.7482

0.0000

1.6100

0.0163

1.0762

0.3145

1.3413

0.0347

1.4187

0.0122

Sencan

−0.8460

0.9362

0.8038

0.8235

0.8674

0.8144

1.0328

0.4006

1.5302

0.0011

0.7247

0.8667

0.8838

0.7312

−1.0674

0.3182

0.8643

0.8983

SenMayo

1.5122

0.0023

1.4982

0.0031

1.4624

0.0052

1.6098

0.0013

1.8501

0.0000

1.5100

0.0362

1.5042

0.0023

1.4586

0.0054

1.4856

0.0020

  1. Note that in GSEA analyses, p values < 0.25 are considered potentially significant, although we also identified p values <0.05 and <0.01 (NES, normalized Enrichment Score). Nominal p value, calculated as two-sided t-test, no adjustment since only one gene set was tested.
Back to article page