Fig. 7: AMPK-α1/α2 deletion precipitated reduced right and left ventricular shortening and volumes. | Nature Communications

Fig. 7: AMPK-α1/α2 deletion precipitated reduced right and left ventricular shortening and volumes.

From: AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Fig. 7

a i-iv Spectral Doppler parasternal long axes obtained using M-mode analysis of the (i and iii) right ventricle (RV), (ii and iv) left ventricle (LV). Dot plots show associated measures of (b) RV and (c) LV volumes for AMPK-α1/α2 floxed controls (AMPK-α1/α2 FLX, n = 4 mice) and AMPK-α1/α2 knockout (AMPK-α1/α2 KO, n = 4 mice for RV volumes and n = 5 mice for LV volumes). Data are expressed as mean ± SEM. Statistical significance was assessed by two-sided unpaired Mann–Whitney’s test.

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