Fig. 3: Differences in the binding site between plant and human cystinosin.
From: Structural basis for proton coupled cystine transport by cystinosin
a Structural superimposition of the plant crystal structure (coloured helices and numbers) and human AlphaFold2 model (grey) revealing the movement of key residues within the binding site. b TEVC data showing the effect of mutations within the binding site of human cystinosin. n = 109 independent experiments for H2O, n = 113 for WT, n = 28 for K273A and D305A, n = 30 for K280A, error bars SEM. Source data are provided as a Source Data file.
