Fig. 7: The systemic anti-tumor immune response induced by PIC + RT + anti-CTLA-4 (C4). | Nature Communications

Fig. 7: The systemic anti-tumor immune response induced by PIC + RT + anti-CTLA-4 (C4).

From: Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade

Fig. 7

a Scheme for the study of the abscopal effect of PIC + RT + anti-CTLA-4. b Average tumor growth curves of both right and left tumor, and c survival rate of mice after the indicated treatment regimen. (n = 9 biologically independent animals). d Individual tumor growth curves in b. CR: complete response. C4: anti-CTLA-4. i.p.: intraperitoneal injection. PIC: 140 μg/100μL/dose. C4: 100 μg/100 μL/dose. Data in b are shown as mean ± SD. The statistical significance was calculated via linear mixed effects modeling in b, and log-rank test in c. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. We compared only the PIC + RT + C4 group with others to specifically test the hypothesis that this combination treatment would achieve greater tumor response and survival compared to doublet combination or control groups. Source data are provided in Source Data file.

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