Fig. 8: Schematic illustration of the mechanisms whereby the multifunctional PIC may potentiate the in situ vaccination effect of RT. | Nature Communications

Fig. 8: Schematic illustration of the mechanisms whereby the multifunctional PIC may potentiate the in situ vaccination effect of RT.

From: Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade

Fig. 8

a The proposed mechanisms of action for PIC in potentiating the in situ vaccination effect of RT. PIC can sensitize tumor cells to RT, capture TAAs released from dying tumor cells, promote the uptake of these captured TAAs in APCs, activate and mature APCs, promote a favorable ratio of M1:M2 TAMs, and increase tumor infiltration by APCs and effector T cells in part by more effectively activating an IFN-I response among radiated cells. b As a result of these mechanisms, PIC combined with RT can help convert a radiated immunologically “cold” tumor to an immunologically “hot” microenvironment.

Back to article page