Fig. 1: Cryo-EM structure of the Omicron spike ectodomain trimer. | Nature Communications

Fig. 1: Cryo-EM structure of the Omicron spike ectodomain trimer.

From: Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape

Fig. 1

a A schematic diagram showing the amino acid mutations of the spike protein. b Cryo-EM map of the Omicron spike protein. Three protomers are colored in medium slate blue, light coral and dark sea green, respectively. The contact interface between down-and up-RBDs is boxed by the red dash line c Atomic structure of the Protomer_A of the Omicron spike with mutations shown as yellow spheres. d Contact interface of the Omicron up-RBD (Protomer_A, A_RBD) and neighboring down-RBD (Protomer_C, C_RBD). e Conformational comparison of the interface between A_RBD and C_RBD of the prototype (PDB: 6ZGG)28 and Omicron. Mutations of Omicron are shown as spheres.

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