Fig. 5: Cytoplasmic force-based regulation of mRNA processing drives meiotic cell division.
From: Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
a Assessment of the first meiotic division in Control, Control + Tubercidin, Control + Pladienolide B, FMN2−/−, FMN2−/− + FMN2 0-h and 5-h rescue contexts; time-lapse images of Prophase SN stage oocytes 6 min prior to entry into division, measured by nuclear envelope breakdown, and 10 to 20 h after nuclear envelope breakdown with illustrations of each approach above; nuclei are outlined in dashed white; arrowheads indicate the extruded polar body, a readout of successful oocyte division. b Quantifications of successful oocyte division in Control, Control + Tubercidin, Control + Pladienolide B, FMN2−/−, FMN2−/− + FMN2 0-h and 5-h rescue contexts shown in percentage of divided cells per experiment; cell number depicted below; P values derived from Fisher’s exact test of proportions, *P = 0.0245, **P < 0.0091, ****P < 0.0001. Scale bar, 5 μm. Source data are provided as a Source Data file.
