Fig. 4: Dopamine synthesis capacity in the putamen predicts methylphenidate effect (relative to placebo) on the prefrontal BOLD signal during unexpected reward versus punishment outcomes. | Nature Communications

Fig. 4: Dopamine synthesis capacity in the putamen predicts methylphenidate effect (relative to placebo) on the prefrontal BOLD signal during unexpected reward versus punishment outcomes.

From: Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning

Fig. 4

a Result of univariate regression analysis showing a linear relationship between dopamine synthesis capacity in the putamen and the effect of methylphenidate on BOLD signal related to unexpected rewards minus unexpected punishments (MPH −  PBO: (unexpected reward − expected reward) − (unexpected punishment − expected punishment); peak voxel: x, y, z = −20, 59, −2, Z = 5.25, pcluster FWE WB = 0.006). Figure conventions are as in Fig. 1b. b Average contrast estimates extracted from the significant clusters in panel a displayed as a function of low and high putamen kicer (median split for visualization). Boxplots and round dots next to distribution kernels are defined as in Fig. 1c. N = 85 participants in both panels. Source data are provided with this paper. MPH methylphenidate, arb. units arbitrary units, kicer dopamine synthesis capacity index.

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