Fig. 1: Sequence alignment of α-, β- and γSyn.
From: Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein
a Each protein comprises three regions: the amphipathic N-region (blue), the amyloidogenic NAC region (pink) and the acidic C-terminal region (red). The sequence identity of βSyn and γSyn to αSyn for each region is shown. The hatched pink region in the centre of NAC for βSyn (Δ) depicts residues in the highly aggregation NAC core (residues 74–84) that are deleted in this sequence. The number of residues in each protein is shown on the right-hand side. b Sequence alignment for each of the paralogues (outlines coloured according to a. Positions of common familial PD mutations of αSyn are highlighted in green and each of the KTKEGV motifs15 involved in membrane binding is highlighted in brown. The ‘master controller’ P1 region is also highlighted in a grey shaded box. “–“ represents a deletion of a residue and “.” represents residue identity at that site.
