Fig. 5: The synthesis of other 6-, 7-, 8-membered azaheterocycles via Pd-catalyzed migratory cycloannulation. | Nature Communications

Fig. 5: The synthesis of other 6-, 7-, 8-membered azaheterocycles via Pd-catalyzed migratory cycloannulation.

From: Construction of azaheterocycles via Pd-catalyzed migratory cycloannulation reaction of unactivated alkenes

Fig. 5

The values under each structure indicate isolated yields (See Supplementary Information for experimental details). Reaction conditions: 1 or 4 (0.4 mmol, 4.0 equiv.), 2 or 6 (0.2 mmol), Pd2(dba)3 (2.8 mg, 1.5 mol%), L8 (4.3 mg, 3.0 mol%), Na2CO3 (53.0 mg, 2.5 equiv.), nBu4NCl (111.2 mg, 2.0 equiv.), DMF (3.0 mL), 80 °C,18 h. For 7 f, 7 m and 7n the reactions were conducted for 36 h. For 9a, 9b and 9c, the reactions were conducted with Pd2(dba)3 (4.6 mg, 2.5 mol%), L8 (7.2 mg, 5.0 mol%). Bn, benzyl; Me, methyl; Ph, phenyl; Ar, aryl; Ac, acetyl; Boc, t-butoxycarbonyl; DMF, N,N-dimethylformamide; ND, not detected.

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