Fig. 1: Timeline of events and longitudinal viral load results.

a Chronology of events in relation to the time point of COVID-19 diagnosis by the first positive SARS-CoV-2 RNA PCR result (day 0). The diagram includes the time points of administration of convalescent plasma, of positive viral cultures from patient respiratory samples on Vero E6 cells, of SARS-CoV-2 genome sequencing, and of first detection of the potential CD8 T cell (1a, 1b, and 2, and 3, see also Fig. 2b) and antibody escape mutations (I, II and III) which are further investigated in this study are indicated. b SARS-CoV-2 RNA copy numbers per ml of endotracheal aspirates and serum are shown over time. Days are indicated in relation to the first positive SARS-CoV-2 RNA result (day 0). Source data are provided in the Source Data file.