Fig. 2: Structure of the PtsG-dependent cytoplasm-entry domain.
From: Proteolytic processing induces a conformational switch required for antibacterial toxin delivery
a Structure of the CdiA-CT•CdiIEC3006 complex. CdiA-CTEC3006 is composed of an N-terminal cytoplasm-entry domain (dark blue) and a C-terminal BECR tRNase (light blue). Side chains for Glu2, Asn3, and Asn4 (of the CdiA-CTEC3006 VENN motif) Tyr5 and the Cys55-Cys65 disulfide are shown as sticks. b Intra-molecular contacts between entry and tRNase domains. c Interactions between adjacent entry domains (in dark blue and yellow) in the crystal lattice.
