Table 2 Multivariate Cox regression analyses for disease-free survival and overall survival in patients with gastric cancer in the training and internal validation cohorts

From: Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer

Variables

Disease-free survival

Overall survival

HR (95% CI)

p

HR (95% CI)

p

Training cohort

 RS

2.118 (1.478–3.035)

<0.0001

1.894 (1.287–2.788)

0.001

Depth of invasion

 T1

0.068 (0.023–0.202)

<0.0001

0.069 (0.020–0.232)

<0.0001

 T2

0.111 (0.035–0.358)

<0.0001

0.159 (0.049–0.515)

0.002

 T3

0.233 (0.105–0.516)

<0.0001

0.206 (0.085–0.495)

<0.0001

 T4a

0.273 (0.159–0.469)

<0.0001

0.258 (0.145–0.458)

<0.0001

 T4b

Reference

   

Lymph node metastasis

 N0

0.319 (0.165–0.616)

0.001

0.286 (0.137–0.597)

0.001

 N1

0.415 (0.229–0.753)

0.004

0.296 (0.151–0.579)

<0.0001

 N2

0.289 (0.134–0.626)

0.002

0.338 (0.147–0.778)

0.011

 N3a

0.551 (0.289–1.051)

0.07

0.554 (0.273–1.121)

0.1

 N3b

Reference

 

Reference

 

 Distant metastasis

3.621 (1.496–8.766)

0.004

\

\

Internal validation cohort 1

 RS

1.659 (1.045–2.634)

0.032

1.744 (1.103–2.757)

0.017

Depth of invasion

 T1

0.134 (0.040–0.444)

0.001

0.103 (0.027–0.388)

0.001

 T2

0.307 (0.095–0.989)

0.048

0.277 (0.088–0.868)

0.028

 T3

0.257 (0.111–0.591)

0.001

0.257 (0.111–0.594)

0.001

 T4a

0.403 (0.235–0.691)

0.001

0.403 (0.228–0.713)

0.002

 T4b

Reference

 

Reference

 

Lymph node metastasis

 N0

0.156 (0.065–0.379)

<0.0001

0.255 (0.103–0.634)

0.003

 N1

0.198 (0.087–0.451)

<0.0001

0.253 (0.102–0.628)

0.003

 N2

0.321 (0.150–0.689)

0.004

0.396 (0.174–0.902)

0.027

 N3a

0.407 (0.191–0.869)

0.02

0.586 (0.265–1.296)

0.187

 N3b

Reference

 

Reference

 

Internal validation cohort 2

 RS

1.478 (1.209–1.806)

0.0001

1.544 (1.243–1.919)

<0.0001

 CEA (elevated versus normal)

1.429 (1.004–2.036)

0.048

1.720 (1.161–2.546)

0.007

 CA19-9 (elevated versus normal)

1.782 (1.300–2.442)

<0.0001

1.598 (1.118–2.285)

0.01

Depth of invasion

 T1

0.148 (0.098–0.224)

<0.0001

0.140 (0.085–0.230)

<0.0001

 T2

0.278 (0.167–0.465)

<0.0001

0.373 (0.216–0.644)

<0.0001

 T3

0.427 (0.200–0.908)

0.027

0.598 (0.265–1.349)

0.215

 T4a

0.405 (0.295–0.555)

<0.0001

0.477 (0.339–0.672)

<0.0001

 T4b

Reference

 

Reference

 

 Distant metastasis

2.471 (1.725–3.542)

<0.0001

2.080 (1.415–3.058)

<0.0001

  1. P values reported are two-tailed from Cox proportional hazard regression analyses.
  2. RS radiomics score, HR hazard ratio.
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