Fig. 1: Mpro cleavage sites in SARS-CoV-2 polyprotein processing. | Nature Communications

Fig. 1: Mpro cleavage sites in SARS-CoV-2 polyprotein processing.

From: X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

Fig. 1

a Schematic overview of the SARS-CoV-2 genome. Open reading frames (ORF) 1a and 1b encode polyproteins pp1a and pp1ab that together contain a total of 11 Mpro cleavage sites (C4-10, C12-C15, red). b Sequence alignment of the SARS-CoV-2 Mpro cleavage-site specificity residues (P6–P6′). Amino acid numbering above P6–P1 is as for C5, the C-terminal autocleavage sequence of Mpro itself, the template into which all other cleavage site P6–P1 sequences were systematically substituted in this study.

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