Table 1 Tfeb overexpression in the epicardium is lethal

From: The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells

 

Total

Gata5+

Tfebfs

Wild-type

Gata5+; Tfebfs

Expected

100%

25%

25%

25%

25%

Stage

At weaning

54

15 (27.8%)

18 (33.3%)

21 (38.9%)

0 (0%)**

At E17.5

29

10 (34.5%)

9 (31.0%)

10 (34.5%)

0 (0%)*

Before E15.5

122

29 (23.8%)

31 (25.4%)

31 (25.4%)

31 (25.4%)

  1. Genotypes of offspring from Gata5+ and Tfebfs crosses. At E17.5, three resorbed embryos were found, two of which had the Gata5+; Tfebfs genotype. The segregation ratio was analyzed with the χ2 test against the expected Mendelian ratio of 1:1:1:1. *p < 0.05, **p < 0.001
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