Fig. 2: Adipocyte-specific deletion of Ldha protects against glucose intolerance and insulin resistance in obese mice. | Nature Communications

Fig. 2: Adipocyte-specific deletion of Ldha protects against glucose intolerance and insulin resistance in obese mice.

From: Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

Fig. 2

Wildtype (WT) and adipocyte-specific Ldha knockout (AKO) mice were fed with standard chow (STC) or high fat diet (HFD) for 4 months. a Body weight of the mice. WT-STC: n = 6; WT-HFD: n = 5; AKO-STC: n = 7; AKO-HFD: n = 9 biologically independent animals. b Body composition of the mice at the end of the treatment. STC-WT: n = 6; STC-AKO: n = 5; HFD-WT: n = 7; HFD-AKO: n = 5 biologically independent animals. c Glucose tolerance test (GTT) and d Area under the curve (AUC) of the GTT. STC-WT: n = 7; STC-AKO: n = 4; HFD-WT: n = 12; HFD-AKO: n = 8 biologically independent animals. e Fasting serum insulin level. STC-WT: n = 8; STC-AKO: n = 5; HFD-WT: n = 10; HFD-AKO: n = 8 biologically independent animals. f, g Insulin tolerance test (ITT). WT-STC: n = 7; WT-AKO: n = 4; WT-HFD: n = 7; AKO-HFD: n = 4 biologically independent animals. h HOMA-IR and i HOMA-β of the mice. WT-STC: n = 7; WT-AKO: n = 4; WT-HFD: n = 7; AKO-HFD: n = 4 biologically independent animals. Data represent mean ± SEM; Significance was calculated by two-way ANOVA with post hoc Bonferroni correction (c-i).

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